Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis
نویسندگان
چکیده
منابع مشابه
Serum bile acids in primary biliary cirrhosis.
Serum bile acid classes have been studied in 15 patients with primary biliary cirrhosis in five patients with cholestasis, and in five patients who had cirrhosis without cholestatic features. Conjugated monohydroxy bile acids (12-35% serum total bile acids) were found in eight of 11 sera from patients with primary biliary cirrhosis, in sera from four patients with cholestasis but not in any of ...
متن کاملExpression of CD44 on bile ducts in primary sclerosing cholangitis and primary biliary cirrhosis.
AIM To examine expression of CD44, a transmembrane glycoprotein involved in lymphocyte homing and activation, in inflammatory liver diseases. METHODS Formalin fixed, paraffin embedded tissues were obtained from normal, uninvolved liver from patients undergoing partial hepatectomy for metastatic carcinoma (9) and transplant hepatectomy specimens from patients with primary biliary cirrhosis (12...
متن کاملBiliary papillomatosis in the common bile duct.
A 62-year-oldwomanwas admitted to our hospital with abdominal pain. Clinical examination revealed definite tenderness in the right hypochondrium only. Laboratory assessment on admission was normal. An abdominal ultrasound was performed, which showed an irregular hyperechoic pseudomass of the gallbladder. An abdominal contrast-enhanced computed tomography (CT) scan (●" Fig.1) and a magnetic reso...
متن کاملBiliary atresia--bile acids and prostaglandin E2 in cell cultures of bile duct epithelia.
In a cell culture model of bile duct epithelial cells, the effect of prostaglandin E2, lithocholic acid and deoxycholic acid was studied. Bile acids and prostaglandin are administered postoperatively in biliary atresia empirically as choleretics. Prostaglandin E2 and the bile acids all had inhibitory effects on bile duct epithelial cells in culture. There is no clinical study proving the effica...
متن کاملBile acids and the Risk for Hepatocellular Carcinoma in Primary Biliary Cholangitis.
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third most common cause of cancer death, and accounts for 5.6% of all cancers. Nearly 82% of the approximately 550,000 liver cancer deaths each year occur in Asia. In some regions, cancer-related death from HCC is second only to lung cancer.1 The most frequent risk factors include chronic viral hepatitis (types ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Autoimmunity
سال: 2016
ISSN: 0896-8411
DOI: 10.1016/j.jaut.2016.08.006